Table 2 Sentinel SNPs significantly associated with heart failure

From: Genetic architecture of heart failure with preserved versus reduced ejection fraction

rsID

Position

Closest gene (* denotes novel association)

Genomic region

Risk allele/Ref. allele

Risk allele frequency

META HF GWAS

MVP HF GWAS

OR (95% CI)

p-value

OR (95% CI)

p-value

rs371236917

1:16310737

SRARP/HSPB7/ZBTB17

Flanking

C/CT

0.70

1.06 (1.05, 1.08)

4.97 × 10−15

1.06 (1.04, 1.08)

1.50 × 10−12

rs1277930

1:109822143

CELSR2

Flanking

A/G

0.77

1.05 (1.04, 1.07)

1.10 × 10−10

1.05 (1.03, 1.07)

7.20 × 10−8

rs7595697

2:11568158

E2F6*

Flanking

T/C

0.37

1.04 (1.02, 1.05)

4.98 × 10−8

1.04 (1.02, 1.05)

1.05 × 10−6

rs6795366

3:44005735

ABHD5*

Intergenic

C/T

0.74

1.05 (1.03, 1.06)

1.95 × 10−8

1.04 (1.02, 1.06)

5.36 × 10−6

rs2634073

4:111665783

PITX2

Intergenic

T/C

0.20

1.08 (1.06, 1.10)

7.42 × 10−19

1.07 (1.05, 1.09)

1.63 × 10−11

rs3176326

6:36647289

CDKN1A

Intron

G/A

0.80

1.08 (1.06, 1.10)

1.08 × 10−18

1.08 (1.06, 1.10)

1.00 × 10−15

rs10455872

6:161010118

LPA

Intron

G/A

0.07

1.11 (1.08, 1.14)

9.34 × 10−17

1.11 (1.08, 1.14)

7.73 × 10−13

rs4717903

7:74068167

GTF2I*

Flanking

C/T

0.25

1.04 (1.03, 1.06)

3.55 × 10−8

1.04 (1.02, 1.06)

1.33 × 10−5

rs4977575

9:22124744

CDKN2B-AS

Intergenic

G/C

0.49

1.07 (1.06, 1.09)

6.92 × 10−23

1.06 (1.05, 1.08)

3.87 × 10−16

rs579459

9:136154168

ABO

Flanking

C/T

0.22

1.05 (1.03, 1.06)

1.26 × 10−8

1.04 (1.02, 1.06)

3.43 × 10−6

rs59693993

10:75583034

CAMK2G

Intron

C/T

0.86

1.06 (1.04, 1.08)

3.08 × 10−8

1.05 (1.03, 1.08)

1.79 × 10−6

rs61869036

10:121422836

BAG3

Intron

G/C

0.79

1.06 (1.04, 1.08)

1.76 × 10−11

1.04 (1.03, 1.06)

3.13 × 10−6

rs12149832

16:53842908

FTO

Intron

A/G

0.41

1.07 (1.05, 1.08)

3.40 × 10−21

1.07 (1.06, 1.09)

9.05 × 10−20

rs12933292

16:69566309

NFAT5*

Intergenic

C/G

0.59

1.04 (1.03, 1.06)

5.25 × 10−9

1.04 (1.03, 1.06)

2.75 × 10−7

rs1002135

17:2097583

SMG6*

Intron

G/T

0.38

1.04 (1.03, 1.06)

6.33 × 10−9

1.04 (1.02, 1.06)

5.89 × 10−7

rs12150603

17:37834715

PNMT/PGAP3*

Intron

G/A

0.35

1.04 (1.03, 1.06)

5.21 × 10−9

1.05 (1.03, 1.06)

5.78 × 10−8

rs150947345

17:57486425

YPEL2*

Flanking

A/T

0.02

1.16 (1.10, 1.22)

1.67 × 10−8

1.16 (1.09, 1.23)

1.62 × 10−6

rs34432450

17:65880259

BPTF*

Intron

C/T

0.21

1.06 (1.04, 1.08)

1.93 × 10−12

1.06 (1.04, 1.08)

3.30 × 10−10

rs79329549

18:36560942

18q12.2*

Intergenic

T/G

0.91

1.07 (1.05, 1.10)

4.60 × 10−9

1.08 (1.05, 1.11)

5.24 × 10−8

rs1999323

21:30534128

MAP3K7CL*

Intron

T/C

0.15

1.07 (1.05, 1.09)

5.26 × 10−11

1.05 (1.03, 1.07)

4.04 × 10−6

  1. Chromosomal position is based on GRCh37/hg19 reference. The sentinel SNPs were mapped to the closest refseq genes based on chromosomal base-pair position. All genetic associations were aligned to effects of the risk alleles (i.e., increased risk for unclassified HF).
  2. Ref reference, OR odds ratio, CI confidence interval, GWAS genome-wide association study, MVP Million Veteran Program cohort (ncases = 43,344), META meta-analysis of MVP and UK Biobank cohorts.
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