Fig. 7: Colocalization analysis of C-GWAS significant findings.
From: Combining genome-wide association studies highlight novel loci involved in human facial variation
Colocalization analysis was carried out for the 56 loci from C-GWAS in 22 tissues from GTEx. a Posterior probabilities in the heatmap are indicated using the box size and the gradience in color (posterior probabilities > 0.7 in solid boxes). Closest genes to the regional lead SNPs are indicated using orange text. Four examples of eQTL colocalizations at distinct loci in different tissues (b–e), where the regional lead SNPs were cis-associated with gene expressions (lower right) and were simultaneously associated with facial variation in C-GWAS (upper right), suggesting that these SNPs are responsible for both the cis-eQTL signal and the C-GWAS signal (left).
