Fig. 4: Concordance of the log (OR) effect estimates for MTAG versus UK single-trait GWAS and 23andMe replication.

Figure 4 shows the comparison of the effect estimates in log (odds ratio) for both basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) based on the respective MTAG approach results versus UKB single-trait GWAS and replication results from 23andMe. The blue line is the line of best fit with the 95% confidence intervals. The blue dots represent loci that overlap between BCC and SCC, whilst the red dots show the loci that are respectively unique to BCC or SCC. The dotted purple lines represent null effects (i.e. log (OR) = 0). The Y- and X- axes represent log (OR). a Shows BCC MTAG versus UKB BCC effect estimates, yielding a high concordance with a Pearson’s correlation of 0.93 (95% confidence interval [CI] = 0.89–0.96, two-sided test). b Shows BCC MTAG versus BCC replication (23andMe) effect estimates, yielding a high concordance i.e. Pearson’s correlation = 0.97 (95% CI = 0.95–0.98, two-sided test). c Shows SCC MTAG versus UKB SCC effect estimates, yielding a high concordance; Pearson’s correlation = 0.71, 95% CI = 0.57–0.81, two-sided test). d Shows SCC MTAG versus SCC replication effect estimates, also resulting in a high correlation i.e. 0.69 (95% CI = 0.55–0.80, two-sided test). UKB- United Kingdom Biobank, and MTAG- multi-trait analysis of GWAS. Source data are provided as a Source Data file.