Fig. 2: Differentially expressed and tissue specific genes of ILCs in the lung and small intestine.
From: Maturation and specialization of group 2 innate lymphoid cells through the lung-gut axis
a–c Differential gene expression of ILC subsets in the lung and the gut was analyzed and shown in Volcano plot. Statistical analysis was performed by using two-tailed unpaired Student’s t-test. Red dots represented the genes highly expressed in the lung, and blue dots represented the genes highly expressed in the gut. d–f GO analysis of differentially expressed genes in the lung and the gut. The orange bars showed the pathways that were enriched in the lung, and the green bars showed the pathways that were enriched in the small intestine. g Normalized relative expression (log(scaled UMI + 1)) levels of the selected tissue specific genes of ILCs displaying on a tSNE plot of Fig. 1b. Cxcr6, Stat5a and Rora were enriched in the intestine ILCs, and Anxa1, Ly6a and S100a4 were highly expressed in the lung ILCs. Selected tissue specific genes for ILC subsets are: Gpr55 for intestine ILC1s, Sell for lung ILC1s, Ccr4 for intestine ILC2s, Ccr2 for lung ILC2s, Ffar2 for intestine ILC3s, and Cd36 for lung ILC3s. Source data are provided as a Source Data file.
