Fig. 8: Gene augmentation preserves visual function of the Prpf31 KO retina. | Nature Communications

Fig. 8: Gene augmentation preserves visual function of the Prpf31 KO retina.

From: Gene augmentation prevents retinal degeneration in a CRISPR/Cas9-based mouse model of PRPF31 retinitis pigmentosa

Fig. 8

a Quantification of ERG scotopic and photopic a- and b-waves amplitudes (n = 8). b ERG recordings of dark-adapted c-waves (n = 8). c Representative scotopic (10 cd·s/m2 flash) and photopic (10 cd·s/m2 flash) ERG recordings 10 weeks (p.i.). Scale bar vertical, 50 uV; Scale bar horizontal, 50 ms. d Representative c-wave recordings 10 weeks (p.i.) Scale bar vertical, 50 uV; Scale bar horizontal, 500 ms. KO-PBS data points and traces are shown in blue; KO-Rescue is shown in red. Data were shown as mean ± SEM. The significance of the overall treatment factor was calculated by two-way ANOVA and shown as a P value in each plot. Significance of the treatment factor at each flash intensity was calculated by Sidak multiple comparisons test and marked as *P < .05; **P < .01; ***P < .001; ****P < .0001. Data of ERG c-waves were analyzed using a two-tailed unpaired t-test. Source data are provided as a Source Data file.

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