Fig. 5: Dose effects of TR length sums on select traits. | Nature Communications

Fig. 5: Dose effects of TR length sums on select traits.

From: Phenome-wide association study of loci harboring de novo tandem repeat mutations in UK Biobank exomes

Fig. 5

Effects of TR length burden on various phenotypes (Ease of skin tanning N = 145,262 participants in (a); Cholesterol concentration N = 148,607 participants in (b); ISOVF in tract superior thalamic radiation N = 18,042 participants in (c); carotid intima medial thickness N = 21,736 participants in (d)) in UK Biobank participants of European ancestry. Each data point represents the mean (±standard error) phenotype measurement at the indicated TR length. Red text denotes several small to medium effect size differences (Cohen’s d and two-sided P-value) between phenotype estimates. Nuclear Receptor Coactivator 6 (NCOA6), nanomoles per liter (nmol/L), Notch Receptor 4 (NOTCH4), isotropic volume fraction (ISOVF), arbitrary unit from magnetic resonance imaging (AU), Butyrophilin Subfamily 2 Member A1 (BTN2A1), FANCD2/FANCI-associated nuclease 1 (FAN1).

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