Fig. 4: Longitudinal profiles of transcriptomic modules. | Nature Communications

Fig. 4: Longitudinal profiles of transcriptomic modules.

From: Multi-omics identify falling LRRC15 as a COVID-19 severity marker and persistent pro-thrombotic signals in convalescence

Fig. 4

a The longitudinal profiles of significant (TxCC, LMM, FDR < 0.05) gene modules, stratified by clinical course. Lines represent estimated marginal means and shaded areas represent their 95% confidence intervals. b Modelled longitudinal profiles of the three genes within module B with the most significant TxCC interaction effects (LMM). Left: lines represent estimated marginal means and shaded areas represent their 95% confidence intervals. Right: individual-level data (n = 169 samples from 40 individuals). c Heatmap displaying associations (LMM) between transcriptomic and proteomic modules (right). Red=positive correlation, blue=negative correlation. Significant associations (5% FDR) are represented by an asterisk.

Back to article page