Fig. 5: Public and cross-reactive clones. | Nature Communications

Fig. 5: Public and cross-reactive clones.

From: Primary exposure to SARS-CoV-2 variants elicits convergent epitope specificities, immunoglobulin V gene usage and public B cell clones

Fig. 5

A Sixteen public clones were identified. Public clones are numbered 1-16 by row, as shown on the far left. Each column of boxes in the middle panel represents a single individual, as labeled at top, and is colored by probe(s) used, as shown at bottom. Right panel shows additional information about each public clone. Light chain information is provided after a colon if a consistent signature was found. Epitopes are inferred from ELISA of RATP-Ig supernatants of at least 1 public clone member; nd, not determined. B CDR H3 logogram for the top public clone, found in 5 of 13 individuals. C–E Combined CDR H3 logograms for 2 public clones using IGHV1-69 and IGKV3-11 with a 15 amino acid CDR H3 length. D 6 public clones using IGHV3-30 with a 14 amino acid CDR H3 length. E 3 public clones using IGHV3-30 with a 10 amino acid CDR H3 length.

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