Fig. 4: The opposing effects of peripheral inflation and width-dependent selection create a quasi-stable equilibrium width. | Nature Communications

Fig. 4: The opposing effects of peripheral inflation and width-dependent selection create a quasi-stable equilibrium width.

From: Evolutionary rescue of resistant mutants is governed by a balance between radial expansion and selection in compact populations

Fig. 4

a Illustration of inflation of sector width due to radial population expansion. b Illustration of constant and width-dependent negative selection in an inflation-free flat front. c, d Schematic graphs of lateral width change per radial colony expansion, ∂rw, for constant (c) and width-dependent (d) selection scenarios, respectively. Yellow lines indicate the contribution of inflation for a given radius r, blue lines indicate the contribution of effective (constant or width-dependent) selection, and black lines represent the sum of both. Note that the slope of the yellow inflation line will gradually decrease as the colony expands. Shaded areas indicate inflation dominated (+, growing clones) or selection dominated (−, shrinking clones) width regions. See Supplementary Figs. 7 and 8 for width dynamics.

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