Fig. 4: The “helped” cDC1 state is transcriptionally related to clinically favorable tumor-infiltrating DC_S3 state.
From: CD4+ helper T cells endow cDC1 with cancer-impeding functions in the human tumor micro-environment
To investigate the relationship between “helped” cDC1 and tumor-infiltrating DC that are conserved across multiple human solid tumor types, the cDC1 “help” signature was cross-compared with a tumor-infiltrating DC3 signature from Gerhard et al.17 and with tumor-infiltrating DC signatures of 8 different states that are associated with either longer or shorter overall patient survival from Luca et al.18. a Venn diagram depicting number of overlapping genes between the cDC1 “help” signature and the tumor-infiltrating DC3 signature. b Heatmaps depicting the expression of tumor-infiltrating DC3 signature genes17 in each DC subset under “help” (aCD4+ T) or “no help” (nCD4+ T) conditions. c Heatmap depicting the expression of signature genes from the indicated tumor-infiltrating DC states (DC_S3 etc.) that are associated with longer or shorter overall survival (OS)18 in cDC1 under “help” (aCD4+ T) or “no help” (nCD4+ T) conditions. d Venn diagrams depicting numbers of overlapping genes between the cDC1 “help” signature and the tumor-infiltrating DC signatures of 8 different states defined in the study of Luca et al.18.
