Table 1 Colistin resistance and heteroresistance of the Enterobacter species

From: Resolving colistin resistance and heteroresistance in Enterobacter species

Enterobacter species (OGRI)

hsp60 cluster

arnBCADTEF gene cassette

Colistin resistance/heteroresistance

Colistin MIC range by BMD (mg/L)

Heteroresistant frequency by PAP (%)

8 mg/L

32 mg/L

E. asburie

I

+

+

128–256

0.44–5.30

0.11–1.20

E. bugandensis

IX

+

+

64–>512

4.10–25.80

1.63–5.28

E. cancerogenus

XIII

+

+

64–128

0.75–1.78

0.24–2.54

E. mori

XIII

+

+

32–64

0.96–1.44

0.53–0.55

E. chengduensis

IV

+

+

64–128

10.35–14.95

6.73–9.05

E. roggenkampii

IV

+

+

64–>512

0–9.70

0–5.38

E. vonholyia

IV

a

a

2–4

0

0

E. cloacae

XI

+

+

512–>512

0–48.38

0.00–24.09

E. cloacae

XII

+

+

512

18.69–24.43

9.49–12.75

E. kobei

II

+

+

8–>512

0–1.19

0–0.55

E. ludwigii

V

+

+

4–256

0–1.07

0–0.14

E. xiangfangensis L-Ib

VIII

+b

+b

2–128

0–0.75

0–0.50

E. xiangfangensis L-II

III

2–4

0

0

E. xiangfangensis L-III

VI

2–4

0

0

E. xiangfangensis L-IV

VI

2–4

0

0

E. wuhouensis

New

4–6

0

0

  1. A total of 165 isolates of different Enterobacter species were studied for their minimum inhibitory concentration (MICLB) and representative isolates of each species were subject to population analysis profile (PAP) test. The MICLB of individual isolates varied in triplicate and often exhibited the “skipped well” phenomenon suggesting heteroresistance. All the isolates carrying intact phoPQ/mgrB/arnBCADTEF genes exhibited MICLB in the range of 2–>512 mg/L. PAP analysis showed heteroresistance frequency of Enterobacter species to vary between none to 48.4%. Different Enterobacter species exhibit different range of MICLB and HRF. Data for individual isolates are presented in Supplementary Data 1b. Key: +: present, −: absent.
  2. aA single isolate of E. xiangfangensis L-1 (RBL-17-0250-3) and a single isolate of E. vonholyi carried truncated phoQ gene.
  3. bThree isolates of E. xiangfangensis (belonging to ST133) lack arnBCADTEF.