Fig. 1: Customizing nanoenzymes inspired by natural ascorbate oxidase for sweat ascorbate sensing.

a Sweat sensors for noninvasive health monitoring, b natural ascorbate oxidase with Cu catalytic and specific binding sites formed by histidine (His) and tryptophan (Trp) for selective catalysis of ascorbate, and c concept of ascorbate oxidase mimicking MOF. The blue, red, gray, and white balls represent Cu, O, C, and H atoms, respectively.