Fig. 4: Relationship between sensitivity and specificity for APRI used to diagnose liver stiffness measurement >12.2 kPa (associated with cirrhosis). | Nature Communications

Fig. 4: Relationship between sensitivity and specificity for APRI used to diagnose liver stiffness measurement >12.2 kPa (associated with cirrhosis).

From: Systematic review and individual-patient-data meta-analysis of non-invasive fibrosis markers for chronic hepatitis B in Africa

Fig. 4

Relationship among A all participants; B asymptomatic screening populations and C patients with suspected liver diseasea. Point estimates at different APRI thresholds are shown as blue (specificity) or orange (sensitivity) dots, connected by straight line segments with 95% credible intervals shown as transparent error bands. aBayesian bivariate random effects model fitted for different thresholds of APRI using 60 equally spaced quantiles. Specificity is defined as the probability of a negative test given the absence of LSM > 12.2; sensitivity is defined as the probability of a positive test, given the presence of LSM > 12.2. Source data are provided as a Source Data file.

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