Fig. 3: Brain penetration of 18F-pretomanid in mouse and rabbit models of TB meningitis.
From: Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
a–d Mice, n = 8. a Coronal 18F-pretomanid and 18F-FDG PET/CT showing the brain lesion and unaffected brain. b Histopathology and 18F-pretomanid autoradiography of the same mouse brain showing brain lesions (white dotted line) and unaffected brain (black dotted line). c Time-activity curves (TACs) from 0 to 60 min for plasma, brain lesions and unaffected brain. d Area under the curve (AUC) ratios (tissue/plasma) in unaffected brain [n = 15 volume of interests (VOIs)] and brain lesion (n = 15 VOIs) (P = 0.055). Each dot represents a VOI. e–h Rabbits, n = 4. e Coronal 18F-pretomanid and 18F-FDG PET/CT in the same rabbit. f Histopathology and 18F-pretomanid autoradiography of the same rabbit brain showing brain lesions (white dotted line) and unaffected brain (black dotted line). g TAC from 0 to 60 min for plasma, unaffected brain, and brain lesions. h AUC ratio (tissue/plasma) comparing unaffected brain (n = 7 VOIs) and brain lesions (n = 7 VOIs). Each dot represents a VOI. PET studies are based on microdoses (ng-µg) administered intravenously. Data are represented as median ± IQR. Statistical comparisons were made using a two-tailed Mann–Whitney-Wilcoxon test. Source data are provided as a Source Data file.
