Fig. 5: First-in-human 18F-pretomanid PET.
From: Dynamic 18F-Pretomanid PET imaging in animal models of TB meningitis and human studies
a Coronal CT and 18F-pretomanid PET maximum-intensity projection (MIP) images. b Representative time-activity curves (TACs) from subject 1 in brain parenchyma and CSF (ventricles) using automated segmentation. A total of 45 volume of interests (VOIs) were analyzed from six subjects. Remaining TACs are shown in Fig. S8. c Transverse 18F-pretomanid PET AUC heat maps demonstrating spatially compartmentalized distribution. d AUC4-55min (tissue/plasma) ratios from the cortex and CSF (ventricles) (P = 0.018). PET studies are based on microdoses (ng-µg) administered intravenously from six human subjects. SUV, standard uptake values. Data are represented as median ± IQR. Statistical comparisons were performed using 2-way ANOVA followed by Bonferroni’s multiple-comparison test. Source data are provided as a Source Data file.
