Fig. 4: Evaluation of SNAP-MS using a molecular network built from reference spectra.

a Subnetworks from a molecular network were created from GNPS public spectral libraries NIH Natural Products Library 1 and NIH Natural Products Library 2. Nodes corresponding to compounds present in the Natural Products Atlas colored green. b–e Predicted compound families for select subnetworks. Molecules present in the original molecular networking subnetwork are indicated with square nodes. The top ranked answers from SNAP-MS are indicated with a bold border.