Fig. 2: Subsequent lung infection by Pseudomonas aeruginosa is more severe following gut colonisation by carbapenemase-producing Enterobacterales (CPE). | Nature Communications

Fig. 2: Subsequent lung infection by Pseudomonas aeruginosa is more severe following gut colonisation by carbapenemase-producing Enterobacterales (CPE).

From: Gut colonisation with multidrug-resistant Klebsiella pneumoniae worsens Pseudomonas aeruginosa lung infection

Fig. 2

a Clinical disease severity score and alveolar-capillary permeability index (n = 11 mice/group). b Bacterial load in P. aeruginosa in the left lung and in the spleen (n = 11 mice/group). c Number of cells in the bronchoalveolar lavage fluid (n = 11 mice/group). d Histological score of lung infection (n = 6 mice/group). Data are presented as mean values ± SD of biologically independent samples from different mice. *p < 0.05; **p < 0.01; ***p < 0.001 (one-way ANOVA followed by Tukey’s post-hoc tests, see the Source Data file for the exact P-values). e Representative images of lung tissue sections stained by haematoxylin and eosin (representative images out of 6 mice/group from two different experiments). Scale bars: 1000 µm (low magnification), 200 µm (high magnification).

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