Fig. 1: Multilevel proteomic atlas of human GC samples. | Nature Communications

Fig. 1: Multilevel proteomic atlas of human GC samples.

From: Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer

Fig. 1: Multilevel proteomic atlas of human GC samples.The alt text for this image may have been generated using AI.

a Workflow of human gastric cancer multilevel proteomic atlas construction. b Differentially expressed proteins in tumor tissues and NATs and their associated biological pathways. Red, upregulated pathways in tumor tissues; blue, upregulated pathways in NATs. c Representative differentially expressed proteins in the cell cycle with multilevel proteomic levels (proteome, TF activity profile, and phospho-proteome). d Regulation network of TFs and their target genes. Tissue-specific TFs are shown. e Phospho-regulatory network in GC. Red, kinases; yellow, substrates. The main function or pathways of substrate proteins are labeled. f The expression of GC signature kinases in multilevel proteomic level (protein, phospho-site, and inferred activity).

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