Fig. 3: Integrated multilevel proteomic analyses showed different pathogenic mechanism of DGC and IGC. | Nature Communications

Fig. 3: Integrated multilevel proteomic analyses showed different pathogenic mechanism of DGC and IGC.

From: Multilevel proteomic analyses reveal molecular diversity between diffuse-type and intestinal-type gastric cancer

Fig. 3: Integrated multilevel proteomic analyses showed different pathogenic mechanism of DGC and IGC.The alt text for this image may have been generated using AI.

a The association of Lauren classification with clinical information. Two-sided Fisher’s exact test is used for categorical variables. b The association of Lauren classification with clinical outcomes. n (DGC) = 83 and n (IGC) = 102 biologically independent samples. P-values are from Log-rank test. c Representative differentially expressed proteins in the featured pathways of DGC and IGC. d Microenvironment scores and immune scores of DGC and IGC. n (DGC) = 83 and n (IGC) = 100 biologically independent samples. Violin plots show median and interquartile range. The p-values are from two-sided Wilcoxon rank-sum test. e Comparison of immune cell infiltration between DGC and IGC. Two-sided Wilcoxon rank-sum test is used. The Benjamini–Hochberg (BH) adjusted p-values are 0.019 (NK cells), 0.0016 (NKT), 1.71E-9 (CD4 + T-cells), 1.89E-12 (CD4 + memory T-cells), 0.0017 (CD8 + T-cells), 0.00056 (CD8 + Tem), and 4.25E-7 (Macrophages). f Integrated analysis of cell cycle regulation pathway at protein, kinase, TF activity and phospho-site levels in DGC and IGC. g Integrated analysis of DNA mismatch repair pathway at protein, kinase and phospho-site levels in DGC and IGC. h The expression of CDK4 and ATR in DGC and IGC. n (DGC) = 10 and n (IGC) = 16 biologically independent samples. Boxplots show median (central line), upper and lower quartiles (box limits), min to max range. The p-values are calculated by two-sided Wilcoxon rank-sum test. i The prognostic analyses of CDK4 and ATR in TCGA cohort. In comparison of CDK4, n (high expression) = 9 and n (low expression) = 13 biologically independent samples. In comparison of ATR, n (high expression) = 32 and n (low expression) = 42 biologically independent samples. The p-value is calculated using Log-rank test. j Summary of signature proteins and pathways involved in DGC and IGC. ****p < 1.0e-4, ***p < 1.0e-3, **p < 0.01, *p < 0.05. Source data are provided as a Source Data file.

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