Fig. 1: Structures of brompheniramine, ixabepilone, alpelisib, and 1–7 and organization of related genes in the cae and knm BGCs.
From: Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors
a Pharmaceuticals containing thiazole and/or pyridine ring. b Structures of karnamicins 1–7, key COSY and HMBC correlations of 1, ORTEP representation (30% probability ellipsoids) of the X-ray structure of compound 7, and isotope labeling result. c Comparison of the organization of the cae BGC from A. cyanogriseus strain NRRL B-2194 and knm BGC from L. rhizosphaerae NEAU-A2.
