Table 1 ACE inhibitory activitya of karnamicins

From: Discovery and biosynthesis of karnamicins as angiotensin converting enzyme inhibitors

Compounds

IC50 (μM)

Compounds

IC50 (μM)

2

1.22 ± 0.02

21

5.36 ± 2.97

5

1.10 ± 0.09

25

5.81 ± 0.47

7

0.30 ± 0.05

29

2.94 ± 0.38

9

0.24 ± 0.01

31

5.42 ± 0.10

10

0.71 ± 0.05

32

0c

11

0.50 ± 0.03

36

0.62 ± 0.07

20

2.58 ± 0.30

Captoprilb

0.014.45 ± 0.51

  1. aResults are expressed as mean IC50 ± standard deviation from n = 3 independent replicates.
  2. bPositive control.
  3. cNo activity at 50 μM.
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