Fig. 7: Illustration of the known cellular processes implicated in YARS1CMT.
From: Tyrosyl-tRNA synthetase has a noncanonical function in actin bundling
The enhanced F-actin bundling properties described for YARS1CMT in this study might contribute to global protein synthesis inhibition, activation of the integrated stress response, transcriptional disregulation, and impaired synaptic vesicle mobility.
