Fig. 1: Selection of SARS-CoV-2 spike variants with antibodies.
From: Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape
a Receptor-Binding Domain (RBD) structure (PDB ID: 7C8J [https://www.rcsb.org/structure/7c8j]) illustrating salient features: yellow = ACE2-binding site; blue = residues changed in BA.1 relative to Wuhan-Hu-1; red = residues changed in BA.2. Highlighted in green are all positions where substitutions were selected by neutralizing antibodies during replication of rVSV/SARS-CoV-2 encoding Wuhan-Hu-1, BA.1, or BA.2 spike proteins. b Substitution frequency at residues along the length of the RBD following passage of rVSV/SARS-CoV-2 encoding Wuhan-Hu-1, BA.1, and BA.2 spike proteins with antibodies.
