Fig. 3: Resistance to broadly neutralizing class 4 and 1/4 antibodies.
From: Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape
Receptor-binding domain (RBD) structure (PDB ID: 7C8J [https://www.rcsb.org/structure/7c8j]) illustrating epitopes of two prototype class 4 antibodies (C022 and C118, yellow), substitutions that confer resistance to class 4 and 1/4 antibodies (green), and pre-existing substitutions in BA.2 (red).
