Fig. 4: Epistatic effects of RBD substitutions on neutralizing antibody sensitivity. | Nature Communications

Fig. 4: Epistatic effects of RBD substitutions on neutralizing antibody sensitivity.

From: Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape

Fig. 4

a Neutralization of the D420N, N460K, and F486S RBD point mutant pseudotypes in Wuhan-Hu-1, BA.1, and BA.2 backgrounds by antibody C3095. b Neutralization of the K444N, L452R, and F490S RBD point mutant pseudotypes indicated in Wuhan-Hu-1, BA.1, and BA.2 backgrounds by antibody B1034. The median value is plotted and the error bars indicate the range of 1–3 independent titrations as detailed in the accompanying source data files.

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