Fig. 5: Pre-existing and escape substitutions in broadly neutralizing class 1 and class 3 antibody epitopes.
From: Epistasis lowers the genetic barrier to SARS-CoV-2 neutralizing antibody escape
a Substitutions that confer context-dependent escape from the class I antibody C099, depicted on the C099:RBD complex structure (PDB ID 7R8L[https://pdbj.org/mine/summary/7r8l]). Green indicates C099 escape substitutions. Blue and red indicate BA.1 and BA.2 substitutions, respectively. C099 heavy and light chains are magenta and yellow respectively. b Substitutions that confer context-dependent escape from C080 class 3 antibody, depicted on the Receptor-Binding Domain (RBD) complex structure (PDB ID 7C8J [https://www.rcsb.org/structure/7c8j]). Yellow indicates the C032 (clonal ancestor of C080) epitope. Green indicates escape substitutions. Blue and red indicate BA.1 and BA.2 substitutions, respectively.
