Fig. 1: Nano-reshaper reprograms systemic and local immune function to enhance specific antitumor immune response against GBM. | Nature Communications

Fig. 1: Nano-reshaper reprograms systemic and local immune function to enhance specific antitumor immune response against GBM.

From: Reprogramming systemic and local immune function to empower immunotherapy against glioblastoma

Fig. 1: Nano-reshaper reprograms systemic and local immune function to enhance specific antitumor immune response against GBM.The alternative text for this image may have been generated using AI.

Nano-reshaper improves systemic immune function such as enhanced thymus and spleen indexes to provide more systemic effector T cells, and overcomes local immunological dysfunction such as the induction of HEVs and upregulated T-cell chemokines to enable T-cell recruitment and facilitates effector T cells infiltration in tumor site. Finally, the increased effector T cells in GBM enhances the response rate of αPD-1. ①: Tumor antigen uptake and presentation; ②: Effector T cells priming and export; ③: Trafficking and infiltration of effector T cells into tumors.

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