Fig. 6: Wearable Mg battery-powered therapeutic devices for psoriasis mouse treatment. | Nature Communications

Fig. 6: Wearable Mg battery-powered therapeutic devices for psoriasis mouse treatment.

From: An integrated Mg battery-powered iontophoresis patch for efficient and controllable transdermal drug delivery

Fig. 6

a Timeline and corresponding photos of normal skin, psoriasis model, and treatment process. b Color change of the Dex-loaded VH20 hydrogel during treatment; the dash area represents the patch size. c Mouse spleen photographs for IMQ-induced, and treated with Dex solution, Dex-loaded VH20 hydrogel, iontophoresis patch, normal model as the control. d Epidermis thickness of psoriasis mouse under different treatments. (n  = 5 biologically independent animals). Data are presented as mean ± SD. *P < 0.05, ** P < 0.01, ***P < 0.001, ****P < 0.0001, ns for no significance, P value was generated by one-way analysis of variance (ANOVA), followed by Tukey’s multiple-comparison post hoc test. e H&E staining of psoriasis mouse skin under different treatments, scale bar: 200 μm. Black arrows: hyperkeratosis; orange arrows: epidermal hyperplasia; red arrows: epidermis; green arrows: cortical layer; yellow arrows: inflammatory cell infiltration.

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