Fig. 6: No evidence for changes in anxiety but impaired social interactions upon combined deletion of LRRTM1 and SynCAM 1. | Nature Communications

Fig. 6: No evidence for changes in anxiety but impaired social interactions upon combined deletion of LRRTM1 and SynCAM 1.

From: Concerted roles of LRRTM1 and SynCAM 1 in organizing prefrontal cortex synapses and cognitive functions

Fig. 6: No evidence for changes in anxiety but impaired social interactions upon combined deletion of LRRTM1 and SynCAM 1.The alternative text for this image may have been generated using AI.

a Model of the elevated plus maze to assess anxiety. Mice are placed in the center of a plus maze and number of entries and length of time spent in open versus closed arms were scored. b WT mice prefer to spend time in the closed arm of the elevated plus maze, and single LRRTM1 and SynCAM 1 KO and DKO mice behave like WT. Dotted lines mark WT times. (One-way ANOVA with Tukey’s post hoc test; n = 16 WT, 18 LRRTM1 KO, 12 SynCAM 1 KO, 11 DKO mice). c Model of the social preference test. Mice are placed between an object and a stranger mouse and sniff zone time around each is recorded. d While LRRTM1 KO and SynCAM 1 KO mice behave like WT and spend more time exploring a stranger mouse than an object, DKO mice show no significant preference. (One-way ANOVA with Tukey’s post hoc test; n = 15 WT, 16 LRRTM1 KO, 15 SynCAM 1 KO, 12 DKO mice). *p < 0.05, ***p < 0.001, n.s., not significant. Error bars show Standard Error of the Mean. Source data for panels b and d are provided as a Source Data file.

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