Fig. 1: Peripheral nerve injury induces activity synchrony in S1.
From: Synchronized activity of sensory neurons initiates cortical synchrony in a model of neuropathic pain
a Schematic showing ECoG recording and Ca2+ imaging of L2/3 pyramidal neurons in S1 HL region in awake behaving SNI mice. Pink inset: ECoG recording; gray inset: SNI surgery. b Spectrograms of ECoG signals in S1 of awake behaving SNI mice. c ECoG power spectra before (Pre), 3 hours, 1 day, and 3 days after SNI. d The mean power in theta band (4–8 Hz). e ECoG power in theta band correlates inversely with mechanical paw withdraw threshold. f Representative two-photon images and fluorescence traces of L2/3 pyramidal neurons in S1 before and after SNI. Arrows point to cells with Ca2+ traces shown below. Scale, 50 μm. g Integrated Ca2+ activity of L2/3 pyramidal neurons in S1. h Representative correlation coefficient matrix of calcium transients from all active neuron pairs in L2/3 of S1. i Correlation coefficient of L2/3 pyramidal neurons in S1 before and after SNI. j Correlation coefficient of L2/3 pyramidal neurons in S1 correlates positively with the mean power in theta band. Data are expressed as mean ± SEM. **P < 0.01, *** P < 0.001. See Table S1 for statistical details. Source data are provided as a Source Data file.
