Fig. 2: Mitochondria in HD neurites contain enlarged granules composed of tightly packed, heterogeneous densities. | Nature Communications

Fig. 2: Mitochondria in HD neurites contain enlarged granules composed of tightly packed, heterogeneous densities.

From: CryoET reveals organelle phenotypes in huntington disease patient iPSC-derived and mouse primary neurons

Fig. 2: Mitochondria in HD neurites contain enlarged granules composed of tightly packed, heterogeneous densities.

Z-slices (~1.4 nm thick) through representative cryoET tomograms of a neurite from a a HD iPSC-neuron (Q77) and b a control iPSC-neuron (Q18), and corresponding oblique cutaway-view segmentations of mitochondrial outer double membranes (yellow) and dense, granular densities inside (light blue), with accompanying zoomed-in views of the mitochondrial granules. Scale bars = 100 nm. Segmentation colors: yellow: double membrane, light blue: mitochondrial granules.

Back to article page