Fig. 7: Fc-mediated effector functions by ShAb molecules.
From: Shark nanobodies with potent SARS-CoV-2 neutralizing activity and broad sarbecovirus reactivity
a ADCP assay using SARS-CoV-2 WA-1 or SARS-CoV-1 Urbani S-2P-labelled beads incubated with phagocytic cells. ADCP scores measure the relative uptake of the bead-labeled proteins. Dotted black line indicates positive control (CR3022), and gray shaded area indicates positivity cutoff as determined by an irrelevant anti-Zika virus antibody (MZ4). b NK cell degranulation in the presence of ShAbs and CoV S-2P. The dotted black line indicates positive control (1:1 mixture of WRAIR-2039 and WRAIR-2123 antibodies for SARS-CoV-2, and CR3022 for SARS-CoV-1). The gray shaded area indicates positivity cutoff as determined by an irrelevant anti-Zika virus antibody (MZ4). Source data are provided as a Source Data file.
