Fig. 1: Monovalent and bivalent mRNA vaccines encoding ancestral, Beta and Delta derived S-protein sequences protect against SARS-CoV-2 variants in a transgenic mouse model. | Nature Communications

Fig. 1: Monovalent and bivalent mRNA vaccines encoding ancestral, Beta and Delta derived S-protein sequences protect against SARS-CoV-2 variants in a transgenic mouse model.

From: Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models

Fig. 1

Female K18-hACE2 mice vaccinated on days 0 and 28 with a total of 0.5 µg CV2CoV (ancestral, orange), 0.5 µg CV2CoV.351 (Beta, light green), 0.5 µg CV2CoV.617.2 (Delta, dark green), CV2CoV.351 + CV2CoV.617.2 (0.25 µg of each; purple) or NaCl (sham; blue) were challenged i.n. with 104.4 TCID50 SARS-CoV-2 variant B.1.351 (Beta) or B.1.617.2 (Delta) at day 56. Animal numbers analysed are summarized in Table S1. a, b Survival curves (Kaplan–Meier) for K18-hACE2 mice challenged with B.1.351 (Beta) (a) or B.1.617.2 (Delta) (b) with follow-up for 10 days post challenge. c–e RT-qPCR results from Day 4 oral swabs (c) or Day 10 conchae (d) and lung (e). Sham group samples were obtained at Day 10 (light blue) or at the humane endpoint (dark blue). Number of RT-qPCR positive and total number of animal sample are shown on the x-axis. Each dot represents one individual mouse. Scatter plots are labelled with median and interquartile range. p-values were determined by two-sided log-rank (Mantel-Cox) test (a, b) or one-way ANOVA and Dunn’s multiple comparison test (c–e). Differences were considered significant at p < 0.05 with exact p-values shown. Source data are provided as a Source Data file.

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