Fig. 2: Bivalent SARS-CoV-2 mRNA vaccines induce abundant virus neutralizing titres. | Nature Communications

Fig. 2: Bivalent SARS-CoV-2 mRNA vaccines induce abundant virus neutralizing titres.

From: Efficacy of an unmodified bivalent mRNA vaccine against SARS-CoV-2 variants in female small animal models

Fig. 2

a–c Mice were vaccinated as described in Fig. S2, 0.5 µg CV2CoV (ancestral, orange), 0.5 µg CV2CoV.351 (Beta, light green), 0.5 µg CV2CoV.617.2 (Delta, dark green), or CV2CoV.351 + CV2CoV.617.2 (0.25 µg of each; purple). Animal numbers analysed are summarized in table S1. Neutralizing antibody (nAb) titres at Day 56 (Pre-challenge) (a), Day 66 (Post-challenge) (b), and surrogate virus-neutralization titres (sVNT) (% inhibition) at Day 56 (Pre-challenge) (c). Each dot represents an individual animal. Scatter plots are labelled with median and interquartile range. p-values were determined by one-way ANOVA and Dunn’s multiple comparison test against CV2CoV (orange) (a–c). d–f Wistar rats were vaccinated on Day 0 and 21 as described in Fig. S4, 8 µg CV2CoV (ancestral, light orange), 8 µg CV2CoV.617.2 (Delta, light green), CV2CoV + CV2CoV.617.2 (4 µg of each; light yellow) or CV2CoV.351 + CV2CoV.617.2 (4 µg of each; light purple) and nAb titres against B.1.617.2 (Delta) or B.1.1.529 (Omicron, BA. 1 and BA.5) were tested at Day 42, the numbers above the bars indicate the fold-differences (d). nAbs titres of each vaccination group against Delta versus Omicron BA.1; (N = 8 individual rats) (d) or nAbs titres from animals vaccinated with equal amounts of CV2CoV.351 versus CV2CoV.617.2 (2 µg CV2CoV.351 light red, 8 µg CV2CoV.351 red, 20 µg CV2CoV.351 dark red, 2 µg CV2CoV.617.2 light green, 8 µg CV2CoV.617.2 green, 20 µg CV2CoV.617.2 dark green) against Omicron BA.1 (e) or BA.5 (f) (N = 6 individual CV2CoV.351 vaccinated rats; N = 8 individual CV2CoV.617.2 vaccinated rats). Each dot represents an individual animal. Scatter plots are labelled with median and interquartile range. The p-values were determined by one-way ANOVA and Dunn’s multiple comparison test. Source data are provided as a Source Data file.

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