Table 1 Main phenotypes observed in the different DLD1 BRCA2-mutated stable cell lines used in this study
From: Replication gap suppression depends on the double-strand DNA binding activity of BRCA2
Cell line | HR | FP | FA | GS HU | GS PARPi | PARPi response | HU response | MMC response |
|---|---|---|---|---|---|---|---|---|
BRCA2 WT | + | + | + | + | + | Resistant | Resistant | Resistant |
BRCA2−/− | − | − | − | − | − | Sensitive | Sensitive | Sensitive |
S273L | + | / | − | − | / | Resistant | Sensitive | mild sens. |
C315S | + | +/− | + | − | + | Resistant | Sensitive | mild sens. |
R3052W | − | +/− | + | + | − | Sensitive | Resistant | Sensitive |
S3291A | / | +/− | + | + | / | / | / | / |
