Fig. 5: Pseudotime analysis of NGM-derived glomerular features identifies distinct glomerular groups along a trajectory of disease progression in IgA nephropathy (IgAN).
From: Next-Generation Morphometry for pathomics-data mining in histopathology
a–a″ Diffusion map embedding of 24,227 glomerular instances with 14 morphometric features with IgAN based on the reported estimated glomerular filtration rate (eGFR) [ml/min/1.73 m²]. b Diffusion map of glomerular instances with pseudotime indicating ordering of glomerular instances along their progression from healthy to diseased. b′ Visualisation of glomerular phenotypes along the pseudotime. c Scaled feature expression heatmap including eGFR along the pseudotime trajectory. d Morphometric progression of glomerular instances in clinical subgroups based on the overall reported eGFR. Scale bar size is 100 µm. Source data are provided as a Source Data file. eGFR estimated glomerular filtration rate, Dim diffusion map, IgAN IgA nephropathy.
