Fig. 4: G protein coupling of RXFP4.
From: Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4)
a Gi-coupling is almost identical among INSL5-, compound 4- and DC591053-bound RXFP4 structures. The alignment is based on the receptor. One salt bridge between helix 8 (H8) and α5 helix of Gi was only found in the compound 4-bound RXFP4-Gi complex. b Comparison of G protein coupling among INSL5-bound RXFP4, FPR2 (PDB code: 7WVV), CCR1 (PDB code: 7VL9) and SSTR2 (PDB code: 7T10). The receptors and G proteins were colored as labeled. c Interaction between RXFP4 (orange) and α5 helix of Gi (salmon) in the cavity of the cytoplasmic region. d Interactions between intracellular loop 2 (ICL2) and Gi. e Interactions between ICL3 and Gi. Polar interactions are shown as black dashed lines.
