Fig. 7: Silencing of Lsd1 and Prmt6 modifies gene expression in SBMA muscle. | Nature Communications

Fig. 7: Silencing of Lsd1 and Prmt6 modifies gene expression in SBMA muscle.

From: LSD1/PRMT6-targeting gene therapy to attenuate androgen receptor toxic gain-of-function ameliorates spinobulbar muscular atrophy phenotypes in flies and mice

Fig. 7

a Venn diagrams showing intersection of differentially expressed genes (top, upregulated; bottom, downregulated; absolute fold-change >4 and adjusted p < 0.01) obtained by comparing control (AR100Q) versus amiR-treated SBMA mice; AR100Q versus WT mice; or amiR-treated versus WT mice. b Ring plot showing the number of differentially expressed genes in AR100Q versus WT mice from differential expression analysis and relative proportions of totally and partially rescued genes. c Heatmap of top 20 clusters obtained from functional enrichment analysis of rescued genes. Color is proportional to enrichment p-values. Each cluster name is based on the most statistically significant term within the cluster. d Similarity network of enriched terms. Each node represents an enriched term and is colored by cluster identifier. Node size is proportional to number of rescued genes in the term. Edge width is proportional with similarity score computed between pairs of nodes.

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