Fig. 1: Diagram for AZL polyketide backbone biosynthesis. | Nature Communications

Fig. 1: Diagram for AZL polyketide backbone biosynthesis.

From: Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition

Fig. 1

Each circle represents an enzymatic domain in the PKS, in which particularly ATa indicates the domain loading a malonyl-CoA to build an acetate unit (single bold line) and ATp to load a methylmalonyl-CoA to build a propionate unit (bold fold line), respectively. The modules and domains involved in this study are highlighted in colors. The red circle labeled with ER in module 3 indicates the missing enoylreductase domain whose enoylreduction is supplied in trans by the ER from module 1/2 and represented by dotted arc arrows. The black circle means that the ER1/2 is non-function during the first round elongation of two successive iterations.

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