Fig. 6: Illustration of the proposed mechanism of cross-module enoylreduction in AZL biosynthesis. | Nature Communications

Fig. 6: Illustration of the proposed mechanism of cross-module enoylreduction in AZL biosynthesis.

From: Insights into azalomycin F assembly-line contribute to evolution-guided polyketide synthase engineering and identification of intermodular recognition

Fig. 6: Illustration of the proposed mechanism of cross-module enoylreduction in AZL biosynthesis.The alternative text for this image may have been generated using AI.

The core of the proposed mechanism is highlighted in the orange box, indicating that only when completion of cross-module enoylreduction, can the reduced and preferred intermediate tethered onto ACP3 transfer to KS4 of module 4.

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