Fig. 1: Reactivity of monoclonal antibodies to modified/non-modified cyclic peptides. | Nature Communications

Fig. 1: Reactivity of monoclonal antibodies to modified/non-modified cyclic peptides.

From: A subset of antibodies targeting citrullinated proteins confers protection from rheumatoid arthritis

Fig. 1: Reactivity of monoclonal antibodies to modified/non-modified cyclic peptides.The alternative text for this image may have been generated using AI.

A library of 108 cyclic 17-mer COL2 peptides covering the whole sequence of mature human COL2 was synthesized (54 citrullinated and 54 corresponding non-modified arginine COL2 peptides) along with other indicated peptides, analysis of antibody specificities was carried out using established bead-based multiplex immunoassay (Luminex) and Log10-transformed MFI values at 1.0 μg/ml antibody concentration are presented as heatmap.

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