Fig. 8: Proposed model for the interplay between genetic patterning, tissue geometry, and mechanical tension in the control of tissue folding.
From: Homeotic compartment curvature and tension control spatiotemporal folding dynamics
Genetic patterning leads to the establishment of in-plane ML apical and basal tension by Dfd-dependent regulation of the apical actomyosin enrichment and basal F-actin fiber organization via Tollo and Dys/Dg. Dfd might regulate Tollo and Dg accumulation via either similar or distinct mechanisms and our data do not exclude that additional Dfd downstream effectors modulate ML tension to promote neck invagination. The existence of putative feedback between apical and basal tension is indicated by question marks (see section “Discussion”).
