Fig. 1: Genetic correlations across 14 autoimmune diseases in European ancestry. | Nature Communications

Fig. 1: Genetic correlations across 14 autoimmune diseases in European ancestry.

From: Multi-ancestry and multi-trait genome-wide association meta-analyses inform clinical risk prediction for systemic lupus erythematosus

Fig. 1: Genetic correlations across 14 autoimmune diseases in European ancestry.The alternative text for this image may have been generated using AI.

Left panel indicates genetic correlations across 14 autoimmune diseases. Genetic correlation is estimated using cross-trait LDSC. Color intensity and size of square are proportional to strength of genetic correlation (brown = negative correlation, green = positive correlation). Asterisks indicate genetic correlations that are statistically significant at false discovery rate level of 0.05. Red boxes highlight the correlation between SLE and other traits. Right panel illustrates the network of significantly genetically-correlated traits. The colors of the lines represent the magnitude of genetic correlation estimates using LDSC. The widths of the lines represent the statistical significance. Disease name abbreviations: AN = ankylosing spondylitis, ATD = autoimmune thyroid disease, CD = Crohn’s disease, CEL = celiac disease, MS = multiple sclerosis, PBC = primary biliary cirrhosis, PSOA = psoriatic arthritis, RA = rheumatoid arthritis, SJO = Sjogren’s syndrome, SLE = systemic lupus erythematosus, SSC = systemic sclerosis, T1D = type 1 diabetes, UC = ulcerative colitis, VIT = vitiligo.

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