Table 1 List of sentinel variants at sixteen replicable novel loci from the multi-ancestry and multi-trait meta-analysis

rsID	Chr:Pos (hg19)	Effect allele	Other allele	Beta	SE	P value	Mapped gene	PMID
rs299629	3:12576846	A	G	−0.061	0.0078	1.0 × 10⁻¹⁴	MKRN2	28378844
rs516124	11:64128423	G	T	0.069	0.0099	3.2 × 10⁻¹²	CCDC88B	25403443
rs6662618	1:92935411	T	G	0.083	0.0122	1.0 × 10⁻¹¹	RPAP2	7962544
rs3761847	9:123690239	G	A	0.051	0.0077	5.1 × 10⁻¹¹	TRAF1	19433411
rs13014122	2:135050622	G	A	0.051	0.0083	5.9 × 10⁻¹⁰	MGAT5	30538706
rs12490565	3:121553719	G	A	−0.054	0.0088	7.5 × 10⁻¹⁰	EAF2	19333917
rs2288786	5:102600754	G	A	0.051	0.0083	1.1 × 10⁻⁹	PAM	16107699
rs9494331	6:136006301	G	A	−0.064	0.0106	1.2 × 10⁻⁹	AHI1	16541099
rs4697651	4:10721433	C	T	0.053	0.0088	1.5 × 10⁻⁹	CLNK	10562326
rs1535271	20:57734753	G	A	0.080	0.0120	6.5 × 10⁻⁹	ZNF831	34552111
rs199533	17:44828931	G	A	0.066	0.0115	1.0 × 10⁻⁸	NSF	25873919
rs12529514	6:14096658	T	C	−0.092	0.0162	1.3 × 10⁻⁸	CD83	23886695
rs2453044	1:120508524	A	G	−0.064	0.0115	2.8 × 10⁻⁸	NOTCH2	20531454
rs6602588	10:12487996	G	A	0.044	0.0080	3.0 × 10⁻⁸	CAMK1D	19815495
rs6939565	6:130194204	C	T	−0.042	0.0076	3.3 × 10⁻⁸	L3MBTL3	15889154
rs12992553	2:70360262	A	G	−0.046	0.0084	4.4 × 10⁻⁸	ASPRV1	29212956, 34766153

We use the reference allele as the effect allele, and report the effect size estimates, standard errors, P values, and mapped target gene based on Open Target database. We also provide key references that describe their biological functions related to SLE. Two-sided P value associated with each variant is calculated according to the Chi-squared test statistic with 1 degree of freedom.

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