Table 1 Clinical data table
From: Distinct tissue niches direct lung immunopathology via CCL18 and CCL21 in severe COVID-19
Study ID | Age range | Sex | PMI [h] | Disease duration [days] | days at ICU | Invasive ventilation | ECMO | Catecholamines | Corticosteroids | ARDS | Bacterial pneumonia | SARS-CoV2 ante mortem | Mean log10_Sars-CoV-2 GE/10000 diploid cells (LUNG | LN) | Subgenomic RNA (LUNG | LN) | Nucleocapsid IHC (LUNG) | Prussian Blue (iron) lung stain | Fibrosis score (mean)/of N slides | COVID-19 as part of main cause of death after autopsya | Technique |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
control case 1 | 90-94 | F | 70 | 1 | 1 | yes | no | no | no | no | yes | Negative | N/A | N/A | N/A | N/A | 0 | + | 2,83/2 | no | MELC (Lung&LN), ST |
control case 2 | 55-59 | M | 36 | 55 | 7 | no | no | no | yes | no | yes | Negative | N/A | N/A | N/A | N/A | 0 | + | 1,9/1 | no | MELC (Lung), ST |
control case 3 | 65-69 | M | 40 | 28 | 7 | yes | yes | yes | no | no | yes | Negative | N/A | N/A | N/A | N/A | 0 | ++ | 1,08/1 | no | ST |
control case 4 | 75-79 | M | 50 | N/A | 0 | no | no | no | no | no | yes | N/A | N/A | N/A | N/A | N/A | N/A | N/A | N/A | no | snRNAseq |
acute case 1 | 80-84 | M | 82 | 11 | N/A | no | no | no | no | yes | no | Positive | 6,67 | 4,85 | yes | yes | +++ | ++ | 2,93/5 | Ib | MELC (Lung), ST, snRNAseq |
acute case 2 | 90-94 | M | 22 | 12 | 3 | no | no | no | yes | yes | yes | Positive | 5,25 | 3,11 | yes | no | ++ | ++ | 1,88/1 | Ic | MELC (Lung&LN), ST |
acute case 3 | 75-79 | M | 30 | 13 | 5 | yes | no | yes | yes | no | yes | Positive | 5,89 | 3,33 | yes | yes | ++ | NA | 2,73/1 | Ib | MELC (Lung&LN), ST, snRNAseq, LSFM |
chronic case 1 | 60-64 | M | 10 | 19 | 13 | yes | no | yes | yes | yes | no | Positive | 2,83 | 1,33 | no | no | + | ++ | 2,68/1 | Ic | MELC (Lung&LN), ST, snRNAseq |
chronic case 2 | 65-69 | M | 30 | 34 | 20 | yes | yes | yes | no | yes | yes | Positive | 1,36 | 2,08 | no | no | 0 | + | 4,71/4 | Ic | MELC (Lung), ST |
chronic case 3 | 55-59 | F | 38 | 27 | 20 | yes | yes | yes | no | yes | yes | Positive | 1,5 | 2,02 | no | no | 0 | 0 | 4,03/5 | Ic | MELC (Lung&LN) |
chronic case 4 | 60-64 | M | 8 | 28 | 0 | no | no | no | no | no | yes | Positive | 2,77 | 0 | no | N/A | N/A | NA | 4,23/1 | Ib | ST |
chronic case 5 | 65-69 | F | 17 | 34 | 30 | yes | yes | yes | yes | yes | yes | Positive | 0,42 | 0 | no | N/A | N/A | N/A | N/A | II | snRNAseq |
prolonged case 1 | 70-74 | M | 116 | 51 | 42 | yes | no | yes | no | yes | no | Positive | 1,7 | 1,37 | no | no | 0 | +++ | 3,48/5 | Ic | MELC (Lung&LN) |
prolonged case 2 | 75-79 | M | 53 | 51 | 51 | yes | no | yes | yes | yes | no | Positive | 0,58 | 1,49 | no | no | 0 | ++ | 3,07/5 | Ic | MELC (Lung) |
prolonged case 3 | 75-79 | M | 84 | 107 | 105 | yes | no | yes | no | no | no | Positive | 0 | 0 | N/A | N/A | N/A | NA | 2,62/1 | Ic | MELC (Lung&LN), ST, snRNAseq |
prolonged case 4 | 70-74 | M | 40 | 51 | 48 | yes | yes | yes | no | yes | yes | Positive | 1,9 | 1,26 | no | no | 0 | +++ | 5,58/5 | Ic | MELC (Lung), ST, LSFM |
prolonged case 5 | 70-74 | M | 3 | 78 | 72 | yes | yes | yes | no | yes | yes | Positive | 1,31 | 0 | no | N/A | 0 | +++ | 5,41/1 | Ic | MELC (Lung&LN), ST, LSFM, snRNAseq |
