Fig. 2: Interactions between EDA·A1THD and EDARCRDS.
a The interaction between EDA·A1THD and EDARCRDS is mainly mediated by CRD2 of EDARCRDS. CRD1, CRD2 and CRD3 are highlighted in limon green, yellow and wheat, respectively. b The electrostatic surface potential of the binding site in EDA·A1THD and EDARCRDS. Three pairs of surface patches with opposite electrostatic properties important for the ligand-receptor interaction are highlighted in dashed circles. Positive potential, blue; negative potential, red. c, d Detailed interactions at patches I and II between EDA·A1THD and EDARCRDS. EDA·A1THD and EDARCRDS are shown in cartoon representation. Residues involved in the interaction are shown in stick models and electrostatic interactions are denoted as magenta dashed lines. e Strand β4 and loop L45 (between strand β4 and helix α1) in EDARCRD2 sit on the saddle-shaped surface of EDA·A1THD. f Detailed interactions at patch III between EDA·A1THD and EDARCRDS. EDA·A1THD and EDARCRDS are shown in cartoons and interacting residues in stick models.
