Fig. 5: TAD-like structures and shape characteristics of Chromosome 21. | Nature Communications

Fig. 5: TAD-like structures and shape characteristics of Chromosome 21.

From: A maximum-entropy model to predict 3D structural ensembles of chromatin from pairwise distances with applications to interphase chromosomes and structural variants

Fig. 5: TAD-like structures and shape characteristics of Chromosome 21.The alternative text for this image may have been generated using AI.

a Comparison of boundary probabilities between experimental imaging data and prediction from DIMES. Boundary probability measures the probability that a genomic locus acts as a single-cell domain boundary. b Comparison of P(Rg) between the experiment and the DIMES predictions. P(Rg) is the probability density distribution of the radius of gyration Rg for the 28–30 Mbp region of Chr21. Comparison of P(κ2) where κ2 is the shape parameter is shown in Supplementary Fig. 10. c The heatmaps of the JSD of the distribution of Rg and κ2 between the experiment and the calculations. Each element (i, j) in the heatmap is the value of JSD for the segment that starts from ith loci and ends at jth loci. Red and blue lines represent two such segments. d Comparison of P(Rg) and P(κ2) between the predictions using DIMES and those calculated using experiments for the segments marked in (c). The blue (red) dot on the left corner of each sub-figure indicates the locations of the segments.

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