Fig. 8: Positive selection on accelerated TFBS groups in the human lineage.
From: Transcription factor binding sites are frequently under accelerated evolution in primates
The numbers of adaptive substitutions per kilobase Dp and the standard errors SE(Dp) are estimated by INSIGHT50,51,52 (Supplementary Table 3). Error bars are centered at the MLE of Dp estimates and indicate two-fold standard errors in each direction. Total number of genetic elements: n = 27,893 (HARs: n = 3098, Pol III binding: n = 286, BDP1 binding sites: n = 439, POU5F1-NANOG binding: n = 1341, POU5F1 binding sites: n = 2040, FOXP2 binding sites: n = 15,881, NANOG binding sites: n = 2952, NRF1 binding sites: n = 1856). P-values were estimated from the one-sided Wald test to compare if Dp is greater than 0. Estimates of Dp found to be significantly greater than 0 are highlighted with stars, ***p < 0.001.
