Fig. 6: Proposed model of upregulated TRIM40-driven IBD initiation and progression.
From: TRIM40 is a pathogenic driver of inflammatory bowel disease subverting intestinal barrier integrity
The upregulated expression of typically epigenetically silenced TRIM40 acts as a pathogenic driver of IBD. The proposed mechanism involves the direct targeting of ROCK1 degradation and cortical actin disruption, which accelerates the destruction of epithelial integrity and function, the transition of short- to long-lived inflammation, and ultimately leads to severe intestinal tissue damage (image created with BioRender.com).
