Fig. 4: Impact of positively charged amino acids near the intracellular signaling on NMR response to anionic lipids. | Nature Communications

Fig. 4: Impact of positively charged amino acids near the intracellular signaling on NMR response to anionic lipids.

From: Anionic phospholipids control mechanisms of GPCR-G protein recognition

Fig. 4

a Location of several charged amino acids near the lipid bilayer boundary. b 19F-NMR spectra of A2AAR[A289CTET] and several A2AAR variants in complex with the agonist NECA in lipid nanodiscs containing only POPC lipids (left column), and in complex with the agonist NECA and in lipid nanodiscs containing a mixture of POPC and POPS lipids at a 70:30 molar ratio (right column). Other figure presentation details the same as in Fig. 1, a and b.

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